GLB1 and Brain atrophy: While our results indicate that SA β‐gal reactivity did not correlate with other senescence markers or brain atrophy, the observed increase in Glb1 gene expression along with a decrease in lysosomal activity at pH 6.0, compared to controls, is suggestive of tau‐associated lysosomal defects, which have been reported by others (Caballero et al., 2018; Wang, Martinez‐Vicente, et al., 2009).