MAPT and Neurofibrillary tangles: This allowed for the evaluation of specific differences in oxygen consumption due to elevated transgenic tau (comparing CTL with tauwt and tauNFT), pathogenic tau‐specific effects (comparing tauwt to tauNFT), as well as the interaction among brains regions and tau expression (e.g., cortex and hippocampus express transgenic tau and develop NFTs, but cerebellum does not).