Consistent with NFTs from human AD, mouse NFTs also caused significant activation scores for IFNG, TNF, and IL‐1B, as well as enrichment in other senescence‐associated JAK, STAT, CDKN2A, and BCL2 predicted upstream regulators (Figure 1c) indicating translational relevance for using tauNFT mice to explore our hypothesis. This evidence concerns the gene TNF and Alzheimer disease.