To begin to examine the human relevance of this work, we assessed levels of transcripts encoded by PCP genes (VANGL1, VANGL2, CELSR1, CELSR2, DISHEVELED 1‐3, FRIZZLED3, PRICKLE1 and PRICKLE2) in glomeruli from biopsies of individuals with either FSGS or MCD from two different cohorts of patients (Table 1). Here, PRICKLE2 is linked to focal segmental glomerulosclerosis.