CDKN2A and lymphoma: In contrast, expression of the AICDA gene (activated by EBNA3C in vitro) was decreased over 500-fold in Δ3C virus-infected (versus WT virus-infected) lymphomas, and expression of four different cellular genes down-regulated by EBNA3C in vitro (CDKN2A, COBLL1, ADAMDEC1, and ADAM28 [26,69]) was significantly increased.