CDKN2A and melanoma: Cyclin E/CDK2 complexes (which are not inhibited by p16), like cyclin D-CDK4/6 complexes, can phosphorylate and inactivate pRb, and both human melanomas and DLBCLs expressing high-level p16 have been reported to escape p16 repression by activating cyclin E expression [56–58].