By comparing the phenotypes of lymphomas containing wild-type (WT) versus EBNA3C-deleted viruses in this model, we have confirmed some previously reported in vitro functions of EBNA3C (inhibition of p16 expression and activation of AICDA expression) and have discovered potentially new functions (including inhibition of T cell infiltration and type 1 interferon signaling). Here, CDKN2A is linked to lymphoma.