MYC and Burkitt lymphoma: Since the pro-apoptotic protein, BIM, is an important tumor suppressor for c-Myc-induced lymphomas [34,41], and EBNA3C inhibits expression of BIM in Burkitt lymphoma cell lines in vitro [42], we performed IHC analysis using antibodies against the EBV latency protein, EBNA1, and BIM to compare BIM expression in WT virus- versus Δ3C virus-infected lymphoma cells.