This is classified as ‘N group’ according to new A/T/N classification[26] and it is regarded as a non-specific marker that can be observed in wide variety of pathologic conditions including AD, cerebrovascular disease, epilepsy, anoxia, hippocampal sclerosis, TDP-43-opathy, primary age-related tauopathy, chronic traumatic encephalopathy, argyrophilic grain disease, and non-AD primary tauopathies [6,7,26–28]. Here, TARDBP is linked to Alzheimer disease.