However, based on this result, we recommend that preventive treatment with prednisone, at the doses above, for HIV-infected TB patients with a CD4 nadir less than 100 cells/μl, who have had hepatitis B and Kaposi's sarcoma excluded, who are not diagnosed with rifampicin-resistant TB and who are symptomatically improving on TB treatment prior to ART. This evidence concerns the gene CD4 and tuberculosis.