IL18 and tuberculosis: A Malaysian study comparing a combined group of patients with paradoxical and unmasking TB-IRIS (n = 15) to controls with TB but no IRIS (n = 14) and those without TB or IRIS (n = 15), using INSHI definitions, found elevated IL-18 and CXCL-10 levels prior to ART to be predictive of TB-IRIS [28].