The evidence on whether increased troponin is associated with stroke was inconsistent: some studies had shown that damage to the right or left insular is associated with higher baseline troponin levels [16, 17], while others had not found any association between insular stroke and troponin levels [18, 19].In our study, 152 were diagnosed as insular stroke, patients with elevated hs-cTnT levels showed significantly higher prevalence of insular stroke, after adjusting for fully confounders, we found a significant association of insular stroke with elevated hs-cTnT level. This evidence concerns the gene TNNT2 and stroke disorder.