Increased NNMT activity and elevations in MeNAM and 2-PY levels have also been reported in type-2 diabetes.57 Increased NNMT activity in tumor cells has been shown to impair polyamine flux.58 Therefore, increased NNMT activity and upregulated levels of MeNAM can alter individual methylation capacity with epigenetic consequences. The gene discussed is NNMT; the disease is type 2 diabetes mellitus.