The exact mechanism underlying the overexpression ofthe H19 lncRNA in CAD patients is not well understood,but one possible explanation for this overexpression isthe involvement of H19 in atherosclerosis (5, 16, 17),the main underlying pathological process responsible forcoronary artery disease, and also in CAD risk factors suchas hyperhomocysteinemia (16, 18, 19), HTN (20), diabetesmellitus (5, 7, 21, 22), and age (23). This evidence concerns the gene H19 and hyperhomocysteinemia.