To reveal whether WAT of patients with RA shows different gene expression profile based on disease itself and/or fat-related inflammation, we investigated the quantitative expression of RARRES2, CMKLR1, SERPINF1, IL6, and IL6-R in WAT of obese RA (BMI: 35.5 ± 4.1 Kg/m2) and OA (BMI: 34.8 ± 3.2). This evidence concerns the gene CMKLR1 and rheumatoid arthritis.