RARRES2 and obesity due to melanocortin 4 receptor deficiency: It should be considered that, in the general population, Chemerin plasma values directly correlate not only with the obesity status, in terms of BMI category, total body fat percentage, waist circumference and total lipids asset but even with multiple markers of chronic inflammation (i.e., CRP, SAA, IL-6, and sTNFRII) suggesting that it may induce extensive inflammatory processes in various chronic inflammatory disorders (37).