IL6 and Sepsis: In the sepsis model, IL-6 is early induced during infection (Figure 1C) (Giai et al., 2016) and a significant correlation between the percentage of splenic MDSC and the levels of circulating IL-6 at the onset of sepsis was observed in both groups of mice (Figure 5C) suggesting that it might be implicated in MDSC accumulation in the spleen.