Myeloid derived suppressor cells (MDSC) have been described as an immature population of cells that is able to suppress T cell responses in polymicrobial sepsis and during chronic and persistent S. aureus infections (Heim et al., 2014; Tebartz et al., 2015) and it has been described that TNF-α participates in their accumulation and activation during chronic inflammation (Sade-Feldman et al., 2013). The gene discussed is TNF; the disease is Sepsis.