In a recent study Al-Khami et al. showed that signaling through STAT3 and STAT5 by the tumor-derived cytokines, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor (GM-CSF), induces expression of lipid transporters and increase the uptake of lipids, which are present at high concentrations in the TME (99). The gene discussed is STAT3; the disease is neoplasm.