TIMP2 and posterior cortical atrophy: De Cicco et al. [7] quantified MMP-2, MMP-9, TIMP-1, and TIMP-2 among other molecules in the plasma of 162 men diagnosed with PCa, having found only a significant association between low MMP-2 values (less than 206 ng/ml) and an worsened disease progression (corrected HR = 1.7 and CI = 95%).