No statistically significant differences were recorded between LRRK2 G2385R-carrier PD group and LRRK2 G2385R-noncarrier PD group (mean AAO: MD = −0.06, 95% CI: −0.15 to 0.03, P=0.19, Supplementary Figure 4A; AAO in early-onset PD: MD = −2.43, 95% CI: −0.55 to 5.42, P=0.11, Supplementary Figure 4B; AAO in late-onset PD: MD = −1.54, 95% CI: −3.38 to 0.30, P=0.10, Supplementary Figure 4C). The gene discussed is LRRK2; the disease is Parkinson disease.