Three studies included an MMSE score analysis in both groups and showed a significantly higher MMSE score in the LRRK2 G2385R-carrier PD group than in the LRRK2 G2385R-noncarrier PD group (MD = 1.02, 95% CI: 0.43–1.62, P=0.0007, Supplementary Figure 8A). The gene discussed is LRRK2; the disease is Parkinson disease.