LRRK2 and Parkinson disease: Available studies have found that LRRK2 G2385R carriers had a higher frequency of family history [3], longer disease duration [4], a lower age at onset [5], a higher proportion of postural instability and gait disorder (PIGD) phenotype [6], and a higher Mini-Mental State Examination (MMSE) score than PD patients who do not carry the LRRK2 G2385R [6].