Moreover, Hong et al., 2016 found that H. pylori infection has a similar effect on the evolution of gastric cancer with IL-1β gene polymorphisms, and the highest amount of severe gastric anomalies occur in patients with high-risk genotypes (cagA(+)/vacAs1(+)/IL-1β-511T) both host and bacterial [40]. This evidence concerns the gene IL1B and gastric cancer.