We noticed increased percentages of GSTM1 deletion for all groups of LC (Supplementary Figure 3A), NSCLC (Supplementary Figure 3B) and mixed LC type (Supplementary Figure 3C); and non-smoker groups (Supplementary Figure 3D) with the increased air pollution (Level 2: < 100, Level 3: 101–250, and Level 4: > 251 deaths/million). The gene discussed is GSTM1; the disease is laryngotracheoesophageal cleft.