MYC and colorectal carcinoma: In particular, the consensus molecular subtypes (CMSs), representing the most robust classification system currently available for CRC, distinguish four molecular groups: CMS1 (hypermutated, microsatellite unstable and strong immune activation), CMS2 (epithelial, high Wnt and Myc signaling activation), CMS3 (epithelial and metabolic dysregulation) and CMS4 (strong transforming growth factor-β activation, stromal invasion and angiogenesis).