To investigate the role of CTGF in the glomerulonephritis model and the contribution of endogenous CTGF expression, we generated a full length of CTGF floxed mice and established tamoxifen-inducible systemic CTGF knockout (Rosa-CTGF cKO) mice by crossing Rosa-CreERT2 mice [37]. The gene discussed is CCN2; the disease is glomerulonephritis.