In addition to the increases in the expression levels of fibrotic makers such as Tgfβ1, Acta2, and Fn1, the glomerular mRNA expression of MCP-1 (Ccl2) and F4/80 (Adgre1) is increased in the control mice with anti-GBM nephritis, and this increase is reduced in the Rosa-CTGF cKO mice with nephritis. The gene discussed is CCN2; the disease is nephritis.