For example, Hypoxanthine-Guanine Phosphoribosyltransferase (HPRT) deficiency [5, 6] and Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) superactivity [7-9] result in uric acid overproduction, which leads to gout. This evidence concerns the gene PRPS1 and gout.