SLC22A12 and gout: In the studies on gout patients from Japan [12-27], Korea [28-30], Iraq [31], China [32], and Czech Republic [33, 34], loss-of-function mutations of SLC22A12 (R90H, R92C, V138M, G164S, R203C, T217M, A226V, R228E, W258X, Q297X, E298D, Q312L, D313A, Q382L, R406C, M430T, L418R, G444R, R477H, A51fsX64, V547fsX602, L415_G417del, IVS2+1G>A, c.935_997delinsTGG) were associated with hypouricemia.