Nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3 (NLRP3) is a component of NLRP3 inflammasome that mediates innate inflammatory responses, and is involved in onset and progression of various diseases, including metabolic disorders, as well as auto-immune and auto-inflammatory diseases [133, 134]. This evidence concerns the gene NLRP3 and metabolic disease.