RUNX2 and cleidocranial dysplasia 1: The term “cleidocranial dysostosis” has been used; however, the syndrome got renamed aptly from cleidocranial dysostosis to cleidocranial dysplasia after the conference for constitutional disorders of bone held in Paris in 1969, given that RUNX2 has important functions both during skeletal formation and in bone maintenance, and CCD is affecting not only the clavicles and the skull but the entire skeleton [1, 2].