LEP and gestational diabetes: Total adiponectin was significantly decreased and leptin more elevated in women with GDM, whereby levels of both adipokines were more distinguishing in women with earlier GDM manifestation compared to NGT (Figure 1, adiponectin: 7.9 ± 3.7 versus 10.4 ± 4.4 μg/ml, p = 0.001; leptin 98.9 ± 36.4 versus 78.0 ± 39.2 μg/ml, p = 0.002).