LEP and gestational diabetes: Both adipokines in early pregnancy < 21st GW were moderate to fair predictive for GDM manifestation, whereby this association was more enhanced in those with early onset < 21st GW as shown in Figure 2 (adiponectin: 0.67, 95% CI: 0.57 to 0.77; leptin: 0.66, 95% CI: 0.57 to 0.74).