The finding of lower levels of fetuin-A in PCOS girls was unexpected and could be derived—at least in part—from the status of low-grade inflammation associated with this entity, since it is known that proinflammatory cytokines and proteins such as CRP—which are increased in PCOS—downregulate fetuin-A expression in the liver [4, 22]. The gene discussed is CRP; the disease is polycystic ovary syndrome.