Similarly, in the largest study of ovarian biopsies done to date, Prentice et al. (4) conducted an immunohistochemical analysis of KISS1 and KISS1R on a tissue microarray consisting of 518 ovarian carcinomas and found that strong KISS1 and KISS1R immunoreactivity was significantly associated with favorable prognosis and overall survival. The gene discussed is KISS1; the disease is ovarian carcinoma.