Moreover, a higher number of the patients without DN received multiple insulin injections per day (≥3 times per day, p = 0.011), although these patients had lower insulin doses per weight (1.17 ± 0.23 and 1.08 ± 0.22 U/kg for patients with and for those without DN, respectively, p = 0.031). Here, INS is linked to liver dysplastic nodule.