In particular, acridine yellow G preferentially blocks cell proliferation of the most malignant U87MG/EGFRvIII cells (PTEN-deficient U87MG glioblastoma cells that overexpress EGFRvIII) over the less malignant PTEN stably transfected U87MG cells (Qi et al., 2012). This evidence concerns the gene PTEN and glioblastoma.