CCN4 and Wilson disease: These data showed that WISP1 protein levels were significant upregulated in PDAC tissues with Tp53 mutation than in PDAC tissues with wild-type Tp53. In addition, a significant correlation was observed between increased malignant phenotype of tumors from WD-PDAC to MD- or PD-PDAC and shift from cytoplasmic expression to nuclear accumulation of WISP1.