Recent studies had shown that WISP1 acts as a new oncogene in glioblastoma (Jing et al., 2017), oral squamous cell carcinoma (Jung et al., 2017), gastric cancer (Jia et al., 2017), melanoma (Shao et al., 2016), and colon cancer (Wu et al., 2016). Here, CCN4 is linked to colonic neoplasm.