KDM6B and Parkinson disease: Suppression of JMJD3 expression per se also induces an exaggerated polarization of microglia into M1 phenotype as illustrated by the expression of genes of pro-inflammatory factors including iNOS, IL1β, and IL6. Finally, in vivo, in an animal model of PD, the suppression of Jmjd3 in the substantia nigra was shown to promote microglial over-activation and thereby exacerbate dopamine neuron loss (Tang et al., 2014).