Indeed, in the SOD1G93A mouse model of ALS, overexpressing the human SOD1 gene carrying a glycine to alanine point mutation at residue 93 (G93A), increased microglial miR-155 expression in the pre-symptomatic mice suggests that this miR could be used as a marker to track ALS at an early stage. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.