EZH2 and experimental autoimmune encephalomyelitis: Furthermore, Ezh2 deficiency in microglia in vivo, achieved by crossing Ezh2 floxed mice with Cx3cr1-CreER mice, confirmed in an animal model of experimental autoimmune encephalomyelitis, that EZH2 facilitates activation of microglia toward a pro-inflammatory M1 phenotype (Zhang et al., 2018).