CSF1R and neoplasm: Among the therapeutic drugs targeting microglia in a preclinical model, the blockage of CSF-1R signaling in glioma-bearing mice, through the anti-CSF-1R antibody Pexidartinib (PLX3397), resulted in a significant reduction tumor infiltration of GAMs and, consequently, a decrease in tumor volume, as well as an apparent increase of the survival time of treated mice (Pyonteck et al., 2013).