IL6 and neoplasm: Sasaki et al. (2004) showed that the GAMs express GLUT5 in non-necrotic areas of the tumor. Moreover, the microglial cells, under glucose deprivation (GD), increase the secretion of IL-6 (Choi et al., 2015) as well as their phagocytic behavior (Churchward et al., 2018). Taking into account that IL-6 and phagocytosis have been associated to M1-like phenotype in microglia (Hambardzumyan et al., 2016), the downregulation of glucose levels in GB or even the inhibition of GLUT5 may be useful to induce M1 polarization in microglial cells and, consequently, reduce the tumor aggressiveness.