CX3CR1 and neoplasm: The CX3CL1 expressed by GB cells induces the human GAMs recruitment through its receptor CX3CR1 and increases the expression of matrix MMPs 2, 9, and 14 in GAMs, which consequently promotes the tumor invasion (Held-Feindt et al., 2010; Carvalho da Fonseca and Badie, 2013; Ferrer et al., 2018).