ABCB1 and central nervous system cancer: Studies have shown that the ABCC1, ABCB1, and ABCA13 are correlated with the level of glioma aggressiveness, with these proteins being overexpressed in high-grade glioma compared to low-grade astrocytoma (de Faria et al., 2008; Balça-Silva et al., 2017a; Dréan et al., 2018).