TIMP1 and central nervous system cancer: In parallel, the downregulation of mRNA expression levels of TIMP metallopeptidase inhibitor 1(TIMP1), TGF-β, and IL-8 in exosomes is correlated with the survival of GB patients after a vaccination with dendritic cell-derived exosomes, which highlights a potential role of EVs in glioma immunotherapy (Muller et al., 2015).