CNTF is synthesized and secreted by gliomas and inhibits T-cell activation and microglia activation. Microglia express CNTF receptor alpha (CNTFRα) and its stimulation with CNTF induces COX2 expression. CNT and CNTFα are expressed by astrocytes. No data in astrocytes–GB crosstalk. Here, CNTF is linked to central nervous system cancer.