HBEGF and neoplasm: Moreover, it was observed in tumor mass border that increased levels of EGF, heparin-binding EGF-like growth factor (HB-EGF), IL-1β, and acidic fibroblast growth factor (FGF1) that correspond to the presence of OPCs and macrophages/microglia are responsible for inducing stem-like phenotype and resistance in GB cells (Hide et al., 2018; Figure 1).