Furthermore, oncology research has suggested that blocking CXCR1 can inhibit the differentiation of breast cancer stem cells (Jia et al., 2017), and that CXCR1 is overexpressed in the development of malignant melanoma and involved in cell growth and angiogenesis (Uen et al., 2015; Jacquelot et al., 2016). Here, CXCR1 is linked to breast cancer.