More clinical reports of patients with mutations in ADNP are needed to determine whether Helsmoortel-van der Aa syndrome should be regarded as part of the SSRIDD spectrum due to the clinical overlap and the functional interaction between ADNP and the SWI/SNF complex (Vandeweyer et al., 2014). This evidence concerns the gene ADNP and ADNP-related multiple congenital anomalies-intellectual disability-autism spectrum disorder.