ADORA2A and Alzheimer disease: More recent data emphasized that A2AR expression is abnormally increased not only in brain cortical parenchyma of AD patients (Orr et al., 2015; Temido-Ferreira et al., 2018) but also on transgenic mouse models (Viana da Silva et al., 2016; Faivre et al., 2018; Lee et al., 2018; Orr et al., 2018; Silva et al., 2018).