The protein expressions of JAK2, STAT3 and VEGF in the NPC tissues were found to share a positive association with the T stage, LNM, N stage and clinical stage (all P < 0.05); however, no significant differences were detected in relation to the expression of JAK2, STAT3 and VEGF proteins among NPC patients with different age, gender, differentiation type, smoking and family history (all P > 0.05) (Table 1). This evidence concerns the gene VEGFA and nasopharyngeal carcinoma.