Regarding the 78 CNP tissues, the positive expressions of JAK2, STAT3 and VEGF were observed in 10 cases (12.8%), 11 cases (14.1%) and 13 cases (16.7%), which indicated that the expressions of JAK2, STAT3 and VEGF in the NPC tissues were significantly higher than those in the CNP tissues (all P < 0.05) (Fig. 1d). This evidence concerns the gene STAT3 and nasopharyngeal carcinoma.