LGR5 and cancer: In other cancer types dynamic and interconverting sub-populations of intestinal CSCs with LGR5+/KI67+, LGR5+/KI67−, LGR5−/KI67+, LGR5−/KI67− expression profiles were reported in patient derived organoid xenografts generated in NOD/SCID mice [63], suggesting existence of various CSC sub-populations in patient tumors.