Considering that lung metastasis appeared to be more accessible to immune cells than liver metastasis (Fig 2F–H), it is noteworthy that mouse p (most densely infiltrated by TILs in the primary tumor) did not show lung metastasis, but many small liver metastasis that were surrounded and greatly outnumbered by CD3+ and, to a lesser extent, CD8+ TILs (Fig. 3E). This evidence concerns the gene CD8A and neoplasm.