By an integrated approach [23] and the use of GSE39683 and GSE47552 public available datasets, a significant inverse correlation with LIG3 mRNA expression was found only for miR-22HG in both datasets, suggesting a potential activity of miR-22 as negative regulator of LIG3 in primary samples from MM patients (Fig. 3a). Here, LIG3 is linked to Miyoshi myopathy.