On melanoma models, IFN-γ and IL-2 were upregulated by either Tα1 or Tα1-Fc in which the concentration of the two cytokines of the Tα1-Fc group showed a significant difference compared with that of the PBS group (p = 0.0016, p = 0.0032) (Fig. 7F). Here, TAAR1 is linked to melanoma.