SUZ12 and EED protein were detected in 18 of 32 (56.25%) and 14 of 32 (43.75%) LMS, respectively, and they were lower than that in uterine leiomyoma (16/16,100%) and normal myometrium (16/16,100%) (p < 0.05). Here, SUZ12 is linked to uterine corpus leiomyoma.