In this study, we detected the expression of EZH2 and three other components of PRC2 in 32 LMS, 51 RMS, 16 uterine leiomyoma, 15 rhabdomyoma as well as 31 normal tissues to evaluate the application value of EZH2 in differential diagnosis. This evidence concerns the gene EZH2 and uterine corpus leiomyoma.