FLI1 and Ewing sarcoma: Similarly, the fusion gene EWS/Friend leukemia integration 1 transcription factor (FLI1) induced EZH2 expression by directly binding to its promotor in Ewing’s sarcoma cell lines11.When the expression levels of micro-RNAs, such as miRs-25, -26a, -101, -138 and -214, were decreased, the expression of EZH2 was increased by interacting directly with the 3′-UTR of EZH2 in malignant tumors27–30.