We evaluated whether hippocampal expression of the four DAC genes share a similar relationship with dementia status and AD pathology as AQP4. While SNTA1 expression did not differ between dementia statuses (Fig. 2B, t = 1.437, padj = 0.226), both DTNA and DAG1 expression in the HIP were significantly increased among subjects with dementia (Fig. 2C,D, t = 2.731, 2.632; padj = 0.009, 0.013; respectively). The gene discussed is AQP4; the disease is Alzheimer disease.