In TCX AQP4 (Fig. 5A; z = 2.32, p = 0.02), DTNA (Fig. 5B; z = 2.16, p = 0.031), and FXYD1 (Fig. 5D; z = 2.39, p = 0.017) all show significant increases in expression in AD subjects, while MLC1 demonstrates only a trend towards increased expression among AD subjects (Fig. 5C, z = 1.82, p = 0.069). The gene discussed is AQP4; the disease is Alzheimer disease.