In the present study, we use human transcriptomic data from aged cognitively-intact and subjects with dementia to demonstrate that changes in the expression of components of the dystrophin-associated complex (DAC), the multi-protein complex that anchors AQP4 to the astrocytic perivascular endfoot, are associated with dementia status and tau pathology in the human cortex. Here, AQP4 is linked to dementia.