EIF2AK4 and infection: In both eif2ak4+/+ and eif2ak4−/− mice, the colonization of AIEC LF82 bacteria was higher and lasted longer compared to that of the non-pathogenic K12 MG1655 bacteria as the LF82 strain was detectable up to day 4 post-infection, whereas the K12 MG1655 strain was cleared since day 1 post-infection (Fig. 2A).