To test whether α1 Na/K-ATPase-mediated Src interaction is important for control of aerobic glycolysis and tumor growth, we knocked down α1 Na/K-ATPase expression in DU145 prostate cancer cells using siRNA and generated stable cell lines A4-7, A4-3 and a control vector-transfected DU-P1 cell line. The gene discussed is SRC; the disease is Familial prostate cancer.