Therefore, during the entire course of their lifespan, cancer cells with an acquired EMT program will remain tdTomato+/EGFP− even if they subsequently lose αSMA or Fsp1 gene expression, or when potentially reverting to an epithelial morphology upon speculated mesenchymal‐to‐epithelial transition (MET) to establish metastatic niches. The gene discussed is ACTA1; the disease is cancer.