To investigate the potential effect of these stressors on the expression of NTT, MIAT and EMX2OS, we used human monocytic cell line THP-1 and glioma cell line KALS1 as models, and treated them with titrations of H2O2 (oxidative stress) or poly (I:C) (TLR3 agonist, mimicking herpes viral infection) for 6 h. Here, TLR3 is linked to central nervous system cancer.