After its initial discovery as an important modulator of Keap1 expression, further investigation demonstrated that ectopic expression of KRAL could sequester miR-141 to upregulate Keap1 expression, repressing the Nrf2-dependent antioxidant pathway and thus reversing the resistance of HCC cells to 5-FU. The gene discussed is KEAP1; the disease is hepatocellular carcinoma.