IL-6 and IL-8 also enable the microenvironment to promote cancer progression by promoting migration and matrix metalloprotease (MMP) production in dermal fibroblasts [74], bone resorption and osteolytic metastases though cyclooxygenase-2 (Cox-2)/prostaglandin E2 (PGE2) [75, 76]. The gene discussed is PTGS2; the disease is cancer.