BRCA1 and breast carcinoma: Given the greater role of the BRCA2 gene in Cypriot familial breast cancer compared to the BRCA1 gene [49, 50], papers have explored the associations between several single-nucleotide-polymorphisms in this gene and breast cancer susceptibility, demonstrating an increased risk amongst women carrying a specific variant of both the BRCA2 and MRE11A genes [51].