PDZK1IP1 and lung adenocarcinoma: In addition, we found that either increased MAP17 mRNA levels in the H1975 cell line or MAP17 silencing in the high-MAP17-expressing lung adenocarcinoma Calu-3 cell line both resulted in reduced sensitivity to bortezomib (p = 0.063, p = 0.045, respectively, Fig. 5c).