PSEN2 and early-onset autosomal dominant Alzheimer disease: In considering the novelty of this reported PSEN2 mutation, a literature search of Medline, the Alzgene genetic database of PSEN2 and the Alzheimer Disease and Frontotemporal Dementia Mutation Databases (AD&FTMD) were completed (www.molgen.vib-ua.be/ADMutations).