NOS2 and infection: Apart from this, it was shown that host sphingosine kinase regulates antimycobacterial responses and its inhibition leads to sensitization of RAW 264.7 macrophage to infection due to reduced expression of anti-mycobacterial effector functions such as pp38, inducible nitric oxide synthase (iNOS) and Lysosome-associated membrane protein 2 (LAMP 2) [12].