Differences in TC features, possibly concealing different TC subpopulations and varying with both GI segment and GI wall layer,24 together with possible site‐specific differences in gene expression,32 could explain how TCs as a whole can originate diverse tumour types, and why, unlike IFPs, PDGFRA‐mutant GISTs show a strong (albeit not entirely exclusive) gastric predilection.33, 34. Here, PDGFRA is linked to neoplasm.