The data herein presented also show a correlation between a predominant glycolytic metabolism of AML cells and activation of AKT in NB‐4 and HL‐60 cells, in agreement with previous observations showing that AKT promotes glycolysis in U937 AML cells.19 Furthermore, the AKT activation exhibited by NB‐4 and HL‐60 cells (Figure 2A) is associated with reduced autophagy flux, indicating that PI3K/AKT/mTORC1 activation seems to drive anabolic metabolism and tumorigenesis in certain AML scenarios by impacting on autophagy. Here, AKT1 is linked to acute myeloid leukemia.