Our findings suggesting that activated AMPK‐autophagy axis is responsible for the augmented oxidative metabolism displayed by KG‐1 cells are in agreement with data obtained in T‐ALL cells and with mixed lineage AML model.52, 54 Furthermore, these studies suggest that the complex nutrient‐sensing network regulating autophagy can have a major impact on AML pathogenesis and response to therapy, including combined therapy with inhibitors of mTOR. This evidence concerns the gene MTOR and acute myeloid leukemia.