ANXA5 and acute myeloid leukemia: To further confirm the distinct energetic metabolism, AML cells were exposed to 2‐deoxy‐d‐glucose (2‐DG), a synthetic glucose analogue that cannot undergo glycolysis.36 Results demonstrated a drastic reduction in NB‐4 and HL‐60 cell's viability with no major impact on the survival of KG‐1 cells, as revealed by the annexin V/PI assay (Figure 1E).