AKT1 and central nervous system cancer: CRNDE, one of the most highly expressed lncRNAs during neuronal differentiation, in induced pluripotent stem cells (iPSCs) and within gliomas32, 35, 50 exerts its oncogenic function by promoting glioma cell growth, invasion and migration through different signalling pathways.51 Acting as a decoy, lncRNAs support glioma progression by reducing miR‐136‐5p expression, directly impacting PI3K/AKT/mTOR signalling pathways.52 Knockdown of CRNDE combined with overexpression of miR‐384 restrained glioma tumour growth and increased survival in a nude mouse model.