Almost 20% of identified lincRNAs reportedly bind to PRC1 or PRC2, whose subcatalytic units (EZH2, SUZ12, CoREST) interact by altering histone code and methylation profile, mainly establishing repressive chromatin states marked by H3K27me3.12 CRNDE regulates gene expression via interacting with EZH2 and CoREST, a repressor of neuronal genes.50 EZH2 is up‐regulated in GBM and appears to be necessary for maintenance of GSC pluripotency and glioma cell proliferation. This evidence concerns the gene EZH2 and central nervous system cancer.