Interestingly, both lncRNAs are also involved in brain development and neuronal differentiation,31, 33 with HOTAIRM1 highly expressed in foetal brain.34 Comparing recurrent glioma samples with primary tumours, CRNDE and HOTAIRM1 were significantly up‐regulated among thousands of differentially expressed lncRNAs. This evidence concerns the gene HOTAIRM1 and central nervous system cancer.