HIF1A and glioblastoma: Moreover, high expression of LOC441204 has been correlated with brain tumour progression, and inhibition of LOC441204 expression resulted in the suppression of tumour cell proliferation in two glioma cell lines.68 Hypoxia‐inducible factor 1 ∝‐antisense RNA 2 (HIF1A‐AS2) is a subtype‐specific hypoxia‐inducible lncRNA that was shown to be overexpressed in mesenchymal GBM stem‐like cells (GSCs).