Several studies have revealed that in general, cancer stem cells can participate in the same reprogramming process as that of iPSCs in maintaining their cell population.77, 78 Interestingly, linc‐ROR, which directly interacts with pluripotency stem cell TFs (SOX2, OCT4 and NANOG) and controls the process of stem cell reprogramming, was identified as an oncogene in several types of cancer, but in glioma, linc‐ROR possesses a tumour‐suppressor function. This evidence concerns the gene POU5F1 and central nervous system cancer.