Conversely, overexpression of HOTAIR in conjunction with I‐BET151 treatment abrogates the anti‐proliferative activity of the BET bromodomain inhibitor in GBM cells.93 The large number of epigenetic dysregulated lncRNAs in glioma reveals that epigenetic inhibitors may induce anti‐tumour effects on brain cancer through modulation of lncRNA networks. The gene discussed is HOTAIR; the disease is central nervous system cancer.