Its expression in GBM is induced by proto‐oncogene c‐MYC, and H19 can further modulate glioma progression by generating the oncomiR‐675, which has as its direct target the cancer‐associated cadherin 13 (CDH13), a tumour‐suppressor protein in several types of cancer.46 H19 knockdown in GBM cell lines was shown to increase TMZ‐induced apoptosis and down‐regulation of GSCs markers, such as CD133, NANOG, OCT4 and SOX2.61 Recently, hypoxia‐induced H19 expression has been reported. This evidence concerns the gene H19 and central nervous system cancer.