Su et al proved the existence of SOX2OT‐miR‐194‐5p/miR‐122‐SOX3‐TDGF‐1 pathway that forms a positive feedback loop that regulates the biological behaviours of GSCs.54 Importantly, SOX2OT is highly evolutionarily conserved and interacts with master regulators of pluripotency and with cancer‐associated genes such as ROCK2 and NFKB. Here, NFKB1 is linked to cancer.