Li W et al have demonstrated that linc‐POU3F3 physically interacts with EZH2, bringing DNMTs to the promoter region in oesophageal squamous cell carcinoma.95 Thereby, this evolutionarily conserved linc‐RNA epigenetically modulates neighbouring gene expression, which could be its common mechanism of action in cancers. The gene discussed is POU3F3; the disease is cancer.