By combining RNA and ChIP‐seq data for H3K4me3 and H3K27me3 marks, the authors found that many disease‐related lncRNAs exhibit aberrant epigenetic modification, and their neighbouring genes are enriched for polycomb repressive protein 2 (PRC2)‐binding sites.92 As an example, foetal tissues and GBM highly express HOTAIRM1,32 showed a gain of H3K4me3 in GSCs compared to that in GBM tissue. This evidence concerns the gene HOTAIRM1 and glioblastoma.