TP53 and glioma: LincRNA‐p21 is a p53‐dependent transcriptional target gene involved in normal cellular proliferation, cell cycle and stem cell reprogramming.30 In iPSC, lincRNA‐p21 prevented reprogramming by activating epigenetic markers to induce heterochromatin at pluripotency gene promoters.80 Moreover, lincRNA‐p21 is down‐regulated in many types of cancer, including gliomas and GSCs, behaving as a tumour suppressor.