Several studies have correlated lncRNA expression profiles with different histological subtypes and malignancy grades in gliomas.32, 36, 37 Global gene expression analyses identified 27 lncRNAs that are differentially expressed between astrocytomas and oligodendrogliomas.32 For GBM, six lncRNAs were found to be significantly associated with patient prognosis but were independent of patient age or MGMT promoter methylation status.38 One transcript, KIAA0495, was abundantly expressed in GBM tissues and associated with reduced survival. The gene discussed is MGMT; the disease is glioblastoma.