Several studies have revealed that in general, cancer stem cells can participate in the same reprogramming process as that of iPSCs in maintaining their cell population.77, 78 Interestingly, linc‐ROR, which directly interacts with pluripotency stem cell TFs (SOX2, OCT4 and NANOG) and controls the process of stem cell reprogramming, was identified as an oncogene in several types of cancer, but in glioma, linc‐ROR possesses a tumour‐suppressor function. The gene discussed is SOX2; the disease is central nervous system cancer.