In a xenograft GBM model, TUG1 was shown to enhance tumour‐induced angiogenesis and VEGF expression through inhibition of miR‐299.64 More importantly, TUG1 is an inducer of GSC differentiation via the Notch pathway, whose increased activity promotes brain tumour growth.65, 66 TUG1 coordinately promotes self‐renewal by sponging miR‐145, a tumour suppressor miRNA, and regulates the stemness‐associated genes SOX2 and c‐Myc. Here, SOX2 is linked to brain neoplasm.