At the same time, linc‐ROR negatively modulates the expression of stem cell factor KLF4, and its restored expression in GBM cells induces the inhibition of GSC proliferation and self‐renewal.79 A previous study showed that TFs such as SOX2, OCT4, NANOG and KLF4 are co‐overexpressed in GBM.77 Therefore, GBM malignancy could be enhanced by the acquisition of pluripotent stem cell (PSC) properties. The gene discussed is KLF4; the disease is glioblastoma.